Estramon Comp

What is Estramon Comp?

Estramon Comp is a continuous combined hormone replacement therapy (HRT) tablet used in women after menopause.

Each film-coated tablet contains:

• Estradiol, a form of estrogen identical to the hormone your ovaries produced before menopause
• Norethisterone acetate, a progestogen that protects the lining of your womb

Estramon Comp is taken every day without interruption. Because it is a continuous combined HRT, both hormones are taken daily. This means regular monthly withdrawal bleeding is usually not expected.

Estramon Comp is prescribed if:

• Your last natural period was at least 12 months ago
• You still have your uterus
• Your menopause symptoms significantly affect your daily life

It is not intended for women in perimenopause or those who still have natural cycles.

What is it used for?

Estramon Comp is used for two main purposes:

1. Relief of menopause symptoms

After menopause, estrogen levels fall. This can lead to symptoms such as:

• Hot flushes
• Night sweats
• Sleep disturbance
• Mood changes
• Vaginal dryness
• Reduced overall wellbeing

Estramon Comp replaces declining estrogen levels and helps reduce these symptoms when they interfere with your quality of life.

2. Prevention of postmenopausal osteoporosis

After menopause, lower estrogen levels can cause bones to become thinner and more fragile. This condition is called osteoporosis.

Estramon Comp may be prescribed to help prevent bone loss if:

• You are at increased risk of fractures
• Other osteoporosis treatments are not suitable for you

How does the product work?

Estramon Comp combines two hormones in one daily tablet to provide balanced hormone replacement therapy.

Estradiol

Estradiol replaces the estrogen your body no longer produces after menopause. It helps:

• Stabilise body temperature regulation
• Reduce hot flushes and night sweats
• Improve vaginal tissue health
• Support sleep and mood
• Maintain bone density

Norethisterone acetate

If you still have your womb, taking estrogen alone increases the risk of thickening of the womb lining (endometrial hyperplasia). Over time, this can increase the risk of endometrial cancer.

Norethisterone acetate protects the lining of your womb by preventing excessive thickening.

Because Estramon Comp is taken continuously, the womb lining remains stable, and regular bleeding is generally avoided.

Who should not use the product?

Do not take Estramon Comp if:

• You have or have had breast cancer
• You have estrogen-dependent cancer (such as endometrial cancer)
• You have unexplained vaginal bleeding
• You have untreated endometrial hyperplasia
• You have or have had blood clots in your legs or lungs
• You have a known clotting disorder
• You have had a heart attack, stroke or angina
• You have liver disease with abnormal liver function
• You have porphyria
• You are pregnant or think you may be pregnant

Stop treatment immediately and seek medical advice if any of these conditions occur during use.

Pregnancy and breastfeeding

Estramon Comp is only intended for postmenopausal women.

Do not take this medication if you are pregnant or breastfeeding.

If you become pregnant while taking Estramon Comp, stop treatment immediately and contact your doctor.

Estramon Comp is not a contraceptive. If it has been less than 12 months since your last period and you are under 50 years old, additional contraception may still be required.

How to use and dosage

The usual dose is:

• One tablet daily
• Taken at approximately the same time each day
• Without interruption between packs

Swallow the tablet with water. It can be taken with or without food.

Your doctor will aim to prescribe the lowest effective dose for the shortest duration necessary to control your symptoms. Your treatment should be reviewed at least once a year.

If you forget a tablet:

• If less than 12 hours late, take it as soon as you remember
• If more than 12 hours late, skip the missed tablet and continue as normal
• Do not take a double dose

Missing tablets may increase the likelihood of breakthrough bleeding.

Possible side effects

Like all hormone replacement therapies, Estramon Comp may cause side effects.

Very common side effects include:

• Headache
• Breast tenderness
• Irregular bleeding, especially during the first months of treatment

Common side effects may include:

• Mood changes or depression
• Nausea
• Abdominal discomfort
• Weight gain
• Fluid retention
• Vaginal discharge
• Migraine or worsening migraine

More serious but less common risks associated with HRT include:

• Breast cancer
• Ovarian cancer
• Endometrial cancer
• Blood clots
• Stroke
• Heart disease

Your individual risk depends on your age, health status, family history and how long you use hormone therapy.

Important safety information

Before starting Estramon Comp, you should have a full medical consultation.

Tell your doctor if you have:

• High blood pressure
• Diabetes
• Migraine
• Liver disease
• Gallstones
• Endometriosis
• Thyroid disorders
• A history of blood clots

Hormone replacement therapy is associated with a small increased risk of venous thromboembolism, especially during the first year of treatment.

You should attend regular check-ups, including breast screening as recommended.

When to seek medical help

Stop taking Estramon Comp and seek urgent medical attention if you experience:

• Painful swelling or redness in one leg
• Sudden chest pain
• Shortness of breath
• Severe sudden headache
• Vision or speech disturbances
• Swelling of the face or throat
• Yellowing of the skin or eyes

Contact your doctor if:

• You develop persistent heavy or unexpected bleeding
• You notice a new breast lump
• Your symptoms worsen
• You experience unusual or severe side effects

If you are unsure whether your symptoms are related to hormone replacement therapy, you can book a secure video consultation with a licensed doctor via Transtoyou. If symptoms are severe or sudden, seek urgent medical care immediately.