Kliovance (Activelle)

Receita médica
  • Daily combined hormone tablet
  • Relieves menopausal symptoms.
  • No monthly bleeding
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Informação do produto

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Verificado Medicamente

Dr. Claudia M. Parada

General Medicine Doctor | REG: 30/4626091
Revisado em: Fevereiro 20, 2026 Ver Perfil

Claudia Muñoz Parada is a licensed family medicine physician, specializing in primary care, pediatrics, and aesthetic medicine.

Kliovance (Activelle) is a daily hormone replacement therapy tablet used to manage estrogen deficiency symptoms in individuals who are postmenopausal. It contains two active ingredients: estradiol, a form of estrogen, and norethisterone acetate, a synthetic progestogen. These hormones are delivered in a continuous combined format, meaning both are taken daily without breaks.

For individuals who have gone through menopause, Kliovance helps reduce symptoms like hot flushes, night sweats, irritability, and sleep disturbances. It restores a stable estrogen level in the body, while norethisterone protects the lining of the uterus from thickening. This makes Kliovance suitable for people with a uterus who want a no-bleed HRT option.

Kliovance is also applicable in the context of feminizing hormone therapy. The estradiol it provides contributes to physical changes such as skin softening and fat redistribution in transgender women. While the norethisterone component is not always needed in feminizing therapy, the product may still be used in certain personalized treatment plans when a continuous oral dose is preferred.

Taken once daily, Kliovance offers convenience and hormonal stability in tablet form. It is suited to those who wish to avoid transdermal methods such as patches or gels. By delivering hormones consistently, Kliovance supports both menopausal relief and long-term feminizing goals.

General Information

What is [Product name]?

Kliovance is a hormone replacement therapy tablet that provides estradiol and norethisterone in a continuous daily dose. It is used for menopause symptom relief. 

What is [Product name] used for?

It is used to relieve symptoms of low estrogen in postmenopausal individuals. 

How does [Product name] work in the body?

Estradiol raises estrogen levels to reduce symptoms or promote feminization. Norethisterone helps protect the uterus in individuals who have one. 

What is the general recommended dosage for [Product name]?

One tablet is taken every day without breaks. This provides a continuous dose of both hormones. 

How long does it take to feel the effects of [Product name]?

Relief of menopause symptoms may begin within a few weeks. 

What should I do if I forget a dose?

Take the tablet as soon as remembered. If it is almost time for the next dose, skip the missed one. Do not take two tablets together. 

Safety & Side Effects

What are the possible side effects of [Product name]?

Possible effects include nausea, breast tenderness, breakthrough bleeding, mood changes, or headaches. Rarely, it may increase the risk of blood clots or hormone-sensitive cancers. 

What are the contraindications of [Product name]?

It should not be used if you have had breast cancer, unexplained vaginal bleeding, blood clots, or liver disease. 

Can I combine [Product name] with other medications?

Yes, but interactions are possible with medicines that affect liver enzymes or hormone levels. Always review your medication list before use. 

Can I use this if I am pregnant or breastfeeding?

No. This product is not suitable for use during pregnancy or while breastfeeding. 

Is it safe to drink alcohol while using [Product name]?

Drinking alcohol in moderation is not known to interfere with the effect of this medication. 

Usage & Administration

How do I administer [Product name]?

Swallow the tablet whole with water at the same time each day. Do not chew or crush. 

How should I store [Product name] properly?

Store in its original packaging at room temperature, away from heat and moisture. 

Should I take [Product name] with food?

It may be taken with or without food, depending on your preference. 

Can I crush or dissolve the tablet in water?

No. The tablet should be swallowed whole to ensure proper release of the medication. 

Ordering & Delivery

How can I order [Product name] online?

To get [Product name], fill out a medical form or book a video consult with a doctor via Transtoyou. After approval, your prescription is sent to the pharmacy for fast delivery.

Do I need a prescription for [Product name]?

[Product name] requires a valid prescription, which is issued after the doctor reviewed your answered in the medical questionnaire or via a video consultation with the doctor.

How fast is [Product name] delivered?

After approval by a doctor from Transtoyou, the prescription of [Product name] is forwarded to an affiliated pharmacy and typically shipped within 1–2 working days.

Can I return [Product name] if I change my mind?

For safety and legal reasons prescription medication (RX) and in this case [Product name] is non-returnable once shipped. 

Documentação do produto

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Kliovance

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